Gating of hippocampal rhythms and memory by synaptic plasticity in inhibitory interneurons.
Neuron
; 109(6): 1013-1028.e9, 2021 03 17.
Article
em En
| MEDLINE
| ID: mdl-33548174
ABSTRACT
Mental experiences can become long-term memories if the hippocampal activity patterns that encode them are broadcast during network oscillations. The activity of inhibitory neurons is essential for generating these neural oscillations, but molecular control of this dynamic process during learning remains unknown. Here, we show that hippocampal oscillatory strength positively correlates with excitatory monosynaptic drive onto inhibitory neurons (EâI) in freely behaving mice. To establish a causal relationship between them, we identified γCaMKII as the long-sought mediator of long-term potentiation for EâI synapses (LTPEâI), which enabled the genetic manipulation of experience-dependent EâI synaptic input/plasticity. Deleting γCaMKII in parvalbumin interneurons selectively eliminated LTPEâI and disrupted experience-driven strengthening in theta and gamma rhythmicity. Behaviorally, this manipulation impaired long-term memory, for which the kinase activity of γCaMKII was required. Taken together, our data suggest that EâI synaptic plasticity, exemplified by LTPEâI, plays a gatekeeping role in tuning experience-dependent brain rhythms and mnemonic function.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina
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Hipocampo
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Interneurônios
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Aprendizagem
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Plasticidade Neuronal
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article