Roles of microRNAs in Gastrointestinal Cancer Stem Cell Resistance and Therapeutic Development.
Int J Mol Sci
; 22(4)2021 Feb 05.
Article
em En
| MEDLINE
| ID: mdl-33562727
ABSTRACT
Resistance to cancer treatment is one of the major challenges currently faced when treating gastrointestinal (GI) cancers. A major contributing factor to this resistance is the presence of cancer stem cells (CSCs) in GI cancers (e.g., colorectal, pancreatic, gastric, liver cancer). Non-coding RNAs, such as microRNAs (miRNAs), have been found to regulate several key targets that are responsible for cancer stemness, and function as oncogenic miRNAs (oncomiRs) or tumor suppressor miRNAs. As a result, several miRNAs have been found to alter, or be altered by, the expression of CSC-defining markers and their related pathways. These miRNAs can be utilized to affect stemness in multiple ways, including directly targeting CSCs and enhancing the efficacy of cancer therapeutics. This review highlights current studies regarding the roles of miRNAs in GI CSCs, and efforts towards the development of cancer therapeutics.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Neoplásicas
/
Resistencia a Medicamentos Antineoplásicos
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MicroRNAs
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Neoplasias Gastrointestinais
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article