Spermidine Attenuates Oxidative Stress-Induced Apoptosis via Blocking Ca<sup>2+</sup> Overload in Retinal Pigment Epithelial Cells Independently of ROS.

Kim, Da Hye; Kim, Jeong-Hwan; Hwangbo, Hyun; Kim, So Young; Ji, Seon Yeong; Kim, Min Yeong; Cha, Hee-Jae; Park, Cheol; Hong, Su Hyun; Kim, Gi-Young; Park, Seh-Kwang; Jeong, Ji-Won; Kim, Mi-Young; Choi, Yung Hyun; Lee, Hyesook

Spermidine Attenuates Oxidative Stress-Induced Apoptosis via Blocking Ca²⁺ Overload in Retinal Pigment Epithelial Cells Independently of ROS.

Kim, Da Hye; Kim, Jeong-Hwan; Hwangbo, Hyun; Kim, So Young; Ji, Seon Yeong; Kim, Min Yeong; Cha, Hee-Jae; Park, Cheol; Hong, Su Hyun; Kim, Gi-Young; Park, Seh-Kwang; Jeong, Ji-Won; Kim, Mi-Young; Choi, Yung Hyun; Lee, Hyesook.

Afiliação

Kim DH; Anti-Aging Research Center, Dong-eui University, Busan 47340, Korea.
Kim JH; Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan 47227, Korea.
Hwangbo H; Research and Development Department, BGN CARE Co., Ltd., Busan 47195, Korea.
Kim SY; Anti-Aging Research Center, Dong-eui University, Busan 47340, Korea.
Ji SY; Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan 47227, Korea.
Kim MY; Anti-Aging Research Center, Dong-eui University, Busan 47340, Korea.
Cha HJ; Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan 47227, Korea.
Park C; Anti-Aging Research Center, Dong-eui University, Busan 47340, Korea.
Hong SH; Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan 47227, Korea.
Kim GY; Anti-Aging Research Center, Dong-eui University, Busan 47340, Korea.
Park SK; Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan 47227, Korea.
Jeong JW; Department of Parasitology and Genetics, Kosin University College of Medicine, Busan 49267, Korea.
Kim MY; Department of Molecular Biology, College of Natural Sciences, Dong-eui University, Busan 47340, Korea.
Choi YH; Anti-Aging Research Center, Dong-eui University, Busan 47340, Korea.
Lee H; Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan 47227, Korea.

Int J Mol Sci ; 22(3)2021 Jan 29.

Article em En | MEDLINE | ID: mdl-33572992

Assuntos

Apoptose; Cálcio/metabolismo; Estresse Oxidativo; Epitélio Pigmentado da Retina/citologia; Espermidina/metabolismo; Antioxidantes/metabolismo; Antioxidantes/farmacologia; Apoptose/efeitos dos fármacos; Linhagem Celular; Humanos; Peróxido de Hidrogênio/metabolismo; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Estresse Oxidativo/efeitos dos fármacos; Espécies Reativas de Oxigênio/metabolismo; Epitélio Pigmentado da Retina/efeitos dos fármacos; Epitélio Pigmentado da Retina/metabolismo; Espermidina/farmacologia

Palavras-chave

cytosolic Ca2+; endoplasmic reticulum stress; oxidative stress; retinal pigment epithelial (RPE) cells; spermidine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espermidina / Cálcio / Apoptose / Estresse Oxidativo / Epitélio Pigmentado da Retina Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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