Pineal hormone melatonin as an adjuvant treatment for COVID19 (Review).
Int J Mol Med
; 47(4)2021 04.
Article
em En
| MEDLINE
| ID: mdl-33576451
ABSTRACT
The beneficial properties of the pineal hormone, melatonin, as a neuroprotective and cardioprotective agent, have been previously identified. Furthermore, melatonin plays essential roles in biological rhythms resynchronization, sleep initiation/maintenance and metabolic, ocular, rheumatological diseases. In addition to these functions, melatonin is known to exert immunomodulation, antiinflammatory and antioxidative effects. Due to these properties, coupled with its nontoxic nature, melatonin has been suggested to limit viral infections; however, melatonin cannot be classified as a viricidal drug. In addition, the recent increase in the number of clinical trials on melatonin's role, as an adjuvant treatment for COVID19, has resurged the interest of the scientific community in this hormone. The present short review aimed to improve the understanding of the antiviral/antiCOVID19 profile of melatonin and the clinical trials that have recently been conducted, with respect to its coadministration in treating individuals with COVID19.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
SARS-CoV-2
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Tratamento Farmacológico da COVID-19
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Melatonina
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article