Glycogen synthase kinase 3ß inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer.

Zhang, Ning; Tian, Yu-Nan; Zhou, Li-Na; Li, Meng-Zhu; Chen, Hua-Dong; Song, Shan-Shan; Huan, Xia-Juan; Bao, Xu-Bin; Zhang, Ao; Miao, Ze-Hong; He, Jin-Xue

Zhang, Ning; Tian, Yu-Nan; Zhou, Li-Na; Li, Meng-Zhu; Chen, Hua-Dong; Song, Shan-Shan; Huan, Xia-Juan; Bao, Xu-Bin; Zhang, Ao; Miao, Ze-Hong; He, Jin-Xue.

Afiliação

Zhang N; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Tian YN; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Zhou LN; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Li MZ; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Chen HD; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Song SS; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Huan XJ; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Bao XB; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Zhang A; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Miao ZH; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
He JX; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Cell Death Dis ; 12(2): 183, 2021 02 15.

Article em En | MEDLINE | ID: mdl-33589588

Assuntos

Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia; Neoplasias Colorretais/tratamento farmacológico; Glicogênio Sintase Quinase 3 beta/antagonistas & inibidores; Inibidores de Poli(ADP-Ribose) Polimerases/farmacologia; Inibidores de Proteínas Quinases/farmacologia; Animais; Linhagem Celular Tumoral; Neoplasias Colorretais/genética; Neoplasias Colorretais/metabolismo; Sinergismo Farmacológico; Feminino; Glicogênio Sintase Quinase 3 beta/metabolismo; Células HCT116; Células HT29; Células HeLa; Recombinação Homóloga/efeitos dos fármacos; Humanos; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Inibidores de Poli(ADP-Ribose) Polimerases/administração & dosagem; Inibidores de Proteínas Quinases/administração & dosagem; Distribuição Aleatória; Transfecção; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Protocolos de Quimioterapia Combinada Antineoplásica / Inibidores de Proteínas Quinases / Inibidores de Poli(ADP-Ribose) Polimerases / Glicogênio Sintase Quinase 3 beta Tipo de estudo: Clinical_trials Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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