Your browser doesn't support javascript.
loading
Antifungal effects of Streptococcus mutans extract on Candida strains susceptible and resistant to fluconazole: An in vivo study.
Alves, Mariana de Sá; Fugisaki, Luciana Ruano de Oliveira; Dos Santos, Jéssica Diane; Scorzoni, Liliana; Medina, Rebeca Previate; Silva, Dulce Helena Siqueira; Junqueira, Juliana Campos.
Afiliação
  • Alves MS; Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, 12245-000, SP, Brazil.
  • Fugisaki LRO; Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, 12245-000, SP, Brazil.
  • Dos Santos JD; Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, 12245-000, SP, Brazil.
  • Scorzoni L; Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, 12245-000, SP, Brazil.
  • Medina RP; Department of Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, 14800-900, SP, Brazil.
  • Silva DHS; Department of Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, 14800-900, SP, Brazil.
  • Junqueira JC; Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, 12245-000, SP, Brazil.
Med Mycol ; 59(7): 744-747, 2021 Jul 06.
Article em En | MEDLINE | ID: mdl-33594432
ABSTRACT
Previous studies showed that the crude extract obtained from Streptococcus mutans inhibited the growth of Candida albicans reference strains. In this study, we evaluated whether the antifungal effects of S. mutans extract can be extended to clinical Candida isolates, including C. albicans and non-abicans strains with different susceptibilities to fluconazole. We verified that S. mutans extract increased the survival of Galleria mellonella larvae infected with C. albicans and C. glabrata and inhibited the fungal cells in hemolymph. These antifungal effects occurred for both fluconazole-susceptible and fluconazole-resistant strains. However, larvae infected by C. krusei were not affected by S. mutans extract. LAY

SUMMARY:

Streptococcus mutans crude extract shows antifungal effects on clinical Candida strains susceptible and resistant to fluconazole in Galleria mellonella model.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Streptococcus mutans / Candida / Candida albicans / Antifúngicos Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Streptococcus mutans / Candida / Candida albicans / Antifúngicos Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article