IL-22 promotes the formation of a MUC17 glycocalyx barrier in the postnatal small intestine during weaning.
Cell Rep
; 34(7): 108757, 2021 02 16.
Article
em En
| MEDLINE
| ID: mdl-33596425
ABSTRACT
The intestine is under constant exposure to chemicals, antigens, and microorganisms from the external environment. Apical aspects of transporting epithelial cells (enterocytes) form a brush-border membrane (BBM), shaped by packed microvilli coated with a dense glycocalyx. We present evidence showing that the glycocalyx forms an epithelial barrier that prevents exogenous molecules and live bacteria from gaining access to BBM. We use a multi-omics approach to investigate the function and regulation of membrane mucins exposed on the BBM during postnatal development of the mouse small intestine. Muc17 is identified as a major membrane mucin in the glycocalyx that is specifically upregulated by IL-22 as part of an epithelial defense repertoire during weaning. High levels of IL-22 at time of weaning reprogram neonatal postmitotic progenitor enterocytes to differentiate into Muc17-expressing enterocytes, as found in the adult intestine during homeostasis. Our findings propose a role for Muc17 in epithelial barrier function in the small intestine.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Interleucinas
/
Glicocálix
/
Intestino Delgado
/
Mucinas
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Animals
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Female
/
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article