Small molecule approaches to treat autoimmune and inflammatory diseases (Part I): Kinase inhibitors.
Bioorg Med Chem Lett
; 38: 127862, 2021 04 15.
Article
em En
| MEDLINE
| ID: mdl-33609659
ABSTRACT
Autoimmune and inflammatory diseases place a huge burden on the healthcare system. Small molecule (SM) therapeutics provide much needed complementary treatment options for these diseases. This digest series highlights the latest progress in the discovery and development of safe and efficacious SMs to treat autoimmune and inflammatory diseases with each part representing a class of SMs, namely 1) protein kinases; 2) nucleic acid-sensing pathways; and 3) soluble ligands and receptors on cell surfaces. In this first part of the series, the focus is on kinase inhibitors that emerged between 2018 and 2020, and which exhibit increased target and tissue selectivity with the aim of increasing their therapeutic index.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases
/
Doenças Autoimunes
/
Inibidores de Proteínas Quinases
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Bibliotecas de Moléculas Pequenas
/
Inflamação
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article