Microcystin-LR induces ovarian injury and apoptosis in mice via activating apoptosis signal-regulating kinase 1-mediated P38/JNK pathway.

Du, Xingde; Liu, Haohao; Liu, Xiaohui; Chen, Xinghai; Yuan, Le; Ma, Ya; Huang, Hui; Wang, Yueqin; Wang, Rui; Zhang, Shiyu; Tian, Zhihui; Shi, Linjia; Zhang, Huizhen

Du, Xingde; Liu, Haohao; Liu, Xiaohui; Chen, Xinghai; Yuan, Le; Ma, Ya; Huang, Hui; Wang, Yueqin; Wang, Rui; Zhang, Shiyu; Tian, Zhihui; Shi, Linjia; Zhang, Huizhen.

Afiliação

Du X; College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Liu H; College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Liu X; School of Basic Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Chen X; Department of Chemistry and Biochemistry, St Mary's University, San Antonio, TX 78228, USA.
Yuan L; College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Ma Y; College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Huang H; College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Wang Y; College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Wang R; College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Zhang S; College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Tian Z; College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Shi L; College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Zhang H; College of Public Health, Zhengzhou University, Zhengzhou 450001, China. Electronic address: huizhen18@126.com.

Ecotoxicol Environ Saf ; 213: 112066, 2021 Apr 15.

Article em En | MEDLINE | ID: mdl-33610944

Assuntos

Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Toxinas Marinhas/toxicidade; Microcistinas/toxicidade; Animais; Apoptose/efeitos dos fármacos; Proteínas Reguladoras de Apoptose; Feminino; MAP Quinase Quinase Quinase 5/metabolismo; Sistema de Sinalização das MAP Quinases/fisiologia; Masculino; Potencial da Membrana Mitocondrial; Camundongos; Camundongos Endogâmicos C57BL; Ovário

Palavras-chave

Apoptosis; Apoptosis signal-regulating kinase 1; Microcystin-LR; Ovarian injury; Reproductive toxicity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema de Sinalização das MAP Quinases / Microcistinas / Toxinas Marinhas Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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