CGRP monoclonal antibody prevents the loss of diffuse noxious inhibitory controls (DNIC) in a mouse model of post-traumatic headache.

Kopruszinski, Caroline M; Turnes, Joelle M; Swiokla, Juliana; Weinstein, Troy J; Schwedt, Todd J; Dodick, David W; Anderson, Trent; Navratilova, Edita; Porreca, Frank

Kopruszinski, Caroline M; Turnes, Joelle M; Swiokla, Juliana; Weinstein, Troy J; Schwedt, Todd J; Dodick, David W; Anderson, Trent; Navratilova, Edita; Porreca, Frank.

Afiliação

Kopruszinski CM; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona, USA.
Turnes JM; Department of Pharmacology, Federal University of Parana, Curitiba, Parana, Brazil.
Swiokla J; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona, USA.
Weinstein TJ; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona, USA.
Schwedt TJ; Department of Neurology, Mayo Clinic, Phoenix, AZ, USA.
Dodick DW; Department of Neurology, Mayo Clinic, Phoenix, AZ, USA.
Anderson T; Department of Biomedical Sciences, College of Medicine, University of Arizona, Phoenix, AZ, USA.
Navratilova E; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona, USA.
Porreca F; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona, USA.

Cephalalgia ; 41(6): 749-759, 2021 05.

Article em En | MEDLINE | ID: mdl-33615840

Assuntos

Concussão Encefálica; Peptídeo Relacionado com Gene de Calcitonina/farmacologia; Controle Inibitório Nociceptivo Difuso/efeitos dos fármacos; Neuralgia; Cefaleia Pós-Traumática/tratamento farmacológico; Animais; Anticorpos Monoclonais; Calcitonina; Capsaicina/farmacologia; Dor Crônica; Modelos Animais de Doenças; Hiperalgesia/etiologia; Hiperalgesia/prevenção & controle; Masculino; Camundongos; Camundongos Endogâmicos C57BL

Palavras-chave

CGRP; Mild traumatic brain injury (mTBI); concussion; conditioned pain modulation (CPM); diffuse noxious inhibitory controls (DNIC); fremanezumab; persistent post-traumatic headache (PPTH); post-traumatic headache (PTH)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Concussão Encefálica / Peptídeo Relacionado com Gene de Calcitonina / Cefaleia Pós-Traumática / Controle Inibitório Nociceptivo Difuso / Neuralgia Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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