Cell-type-specific recruitment of GABAergic interneurons in the primary somatosensory cortex by long-range inputs.
Cell Rep
; 34(8): 108774, 2021 02 23.
Article
em En
| MEDLINE
| ID: mdl-33626343
ABSTRACT
Extensive hierarchical yet highly reciprocal interactions among cortical areas are fundamental for information processing. However, connectivity rules governing the specificity of such corticocortical connections, and top-down feedback projections in particular, are poorly understood. We analyze synaptic strength from functionally relevant brain areas to diverse neuronal types in the primary somatosensory cortex (S1). Long-range projections from different areas preferentially engage specific sets of GABAergic neurons in S1. Projections from other somatosensory cortices strongly recruit parvalbumin (PV)-positive GABAergic neurons and lead to PV neuron-mediated feedforward inhibition of pyramidal neurons in S1. In contrast, inputs from whisker-related primary motor cortex are biased to vasoactive intestinal peptide (VIP)-positive GABAergic neurons and potentially result in VIP neuron-mediated disinhibition. Regardless of the input areas, somatostatin-positive neurons receive relatively weak long-range inputs. Computational analyses suggest that a characteristic combination of synaptic inputs to different GABAergic IN types in S1 represents a specific long-range input area.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Somatossensorial
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Vibrissas
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Células Piramidais
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Transmissão Sináptica
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Neurônios GABAérgicos
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Ácido gama-Aminobutírico
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Interneurônios
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Inibição Neural
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article