Protective effect of SIRT6 on cholesterol crystal-induced endothelial dysfunction via regulating ACE2 expression.

Zheng, Zihan; Wang, Bo; Lv, Xiaohan; Yao, Feng; Gao, Hongqian; Jin, Zhen; Liu, Yizhen; Deng, Ying; Chen, Danli; Ning, Xuan; Wang, Weirong; He, Jianyu; Lin, Rong

Zheng, Zihan; Wang, Bo; Lv, Xiaohan; Yao, Feng; Gao, Hongqian; Jin, Zhen; Liu, Yizhen; Deng, Ying; Chen, Danli; Ning, Xuan; Wang, Weirong; He, Jianyu; Lin, Rong.

Afiliação

Zheng Z; Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Wang B; Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Lv X; Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Yao F; Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Gao H; Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Jin Z; Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Liu Y; Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Deng Y; Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Chen D; Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Ning X; Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Wang W; Department of Medical Experiment Animal Science, Xi'an, Shaanxi, 710061, China.
He J; Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China. Electronic address: hejianyu@mail.xjtu.edu.cn.
Lin R; Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China. Electronic address: linrong@mail.xjtu.edu.cn.

Exp Cell Res ; 402(1): 112526, 2021 05 01.

Article em En | MEDLINE | ID: mdl-33631165

Assuntos

Fator 2 Ativador da Transcrição/genética; Enzima de Conversão de Angiotensina 2/genética; Doenças Cardiovasculares/genética; Colesterol/metabolismo; Sirtuína 1/genética; Sirtuínas/genética; Doenças Cardiovasculares/metabolismo; Doenças Cardiovasculares/patologia; Colesterol/genética; Células Endoteliais/metabolismo; Regulação da Expressão Gênica/genética; Células Endoteliais da Veia Umbilical Humana; Humanos; Óxido Nítrico/metabolismo; Óxido Nítrico Sintase Tipo III/genética; Estresse Oxidativo/genética; Transdução de Sinais/genética

Palavras-chave

ACE2; Cholesterol crystals; Endothelial dysfunction; SIRT6; p-ATF2

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Colesterol / Sirtuínas / Fator 2 Ativador da Transcrição / Sirtuína 1 / Enzima de Conversão de Angiotensina 2 Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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