Inhibitors of endosomal acidification suppress SARS-CoV-2 replication and relieve viral pneumonia in hACE2 transgenic mice.

Shang, Chao; Zhuang, Xinyu; Zhang, He; Li, Yiquan; Zhu, Yilong; Lu, Jing; Ge, Chenchen; Cong, Jianan; Li, Tingyu; Tian, Mingyao; Jin, Ningyi; Li, Xiao

Shang, Chao; Zhuang, Xinyu; Zhang, He; Li, Yiquan; Zhu, Yilong; Lu, Jing; Ge, Chenchen; Cong, Jianan; Li, Tingyu; Tian, Mingyao; Jin, Ningyi; Li, Xiao.

Afiliação

Shang C; Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, 130122, People's Republic of China.
Zhuang X; Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, 130122, People's Republic of China.
Zhang H; Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, 130122, People's Republic of China.
Li Y; Academician Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, 130117, People's Republic of China.
Zhu Y; Academician Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, 130117, People's Republic of China.
Lu J; Agricultural College, Yanbian University, Yanji, 133002, People's Republic of China.
Ge C; Agricultural College, Yanbian University, Yanji, 133002, People's Republic of China.
Cong J; Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, 130122, People's Republic of China.
Li T; Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, 130122, People's Republic of China.
Tian M; Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, 130122, People's Republic of China. linjiaxiaoya@163.com.
Jin N; Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, 130122, People's Republic of China. lixiao06@mails.jlu.edu.cn.
Li X; Academician Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, 130117, People's Republic of China. lixiao06@mails.jlu.edu.cn.

Virol J ; 18(1): 46, 2021 02 27.

Article em En | MEDLINE | ID: mdl-33639976

Assuntos

Antivirais/farmacologia; Tratamento Farmacológico da COVID-19; COVID-19/virologia; Endossomos/efeitos dos fármacos; SARS-CoV-2/efeitos dos fármacos; SARS-CoV-2/fisiologia; Replicação Viral/efeitos dos fármacos; Cloreto de Amônio/farmacologia; Enzima de Conversão de Angiotensina 2/genética; Enzima de Conversão de Angiotensina 2/metabolismo; Animais; COVID-19/metabolismo; COVID-19/patologia; Sobrevivência Celular/efeitos dos fármacos; Chlorocebus aethiops; Cloroquina/farmacologia; Endossomos/metabolismo; Feminino; Células HEK293; Humanos; Concentração de Íons de Hidrogênio; Pulmão/patologia; Macrolídeos/farmacologia; Camundongos; Camundongos Transgênicos; Distribuição Aleatória; SARS-CoV-2/genética; Células Vero

Palavras-chave

Bafilomycin A1; Chloroquine; Endosomal acidification; SARS-CoV-2

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Endossomos / Replicação Viral / SARS-CoV-2 / COVID-19 / Tratamento Farmacológico da COVID-19 Tipo de estudo: Clinical_trials Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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