Nuclear translocation of ATG5 induces DNA mismatch repair deficiency (MMR-D)/microsatellite instability (MSI) via interacting with Mis18&#945; in colorectal cancer.

Sun, Shi-Yue; Hu, Xue-Tao; Yu, Xin-Feng; Zhang, Yue-Ying; Liu, Xiao-Hui; Liu, Yuan-Hang; Wu, Shu-Hua; Li, Yang-Yang; Cui, Shu-Xiang; Qu, Xian-Jun

Nuclear translocation of ATG5 induces DNA mismatch repair deficiency (MMR-D)/microsatellite instability (MSI) via interacting with Mis18α in colorectal cancer.

Sun, Shi-Yue; Hu, Xue-Tao; Yu, Xin-Feng; Zhang, Yue-Ying; Liu, Xiao-Hui; Liu, Yuan-Hang; Wu, Shu-Hua; Li, Yang-Yang; Cui, Shu-Xiang; Qu, Xian-Jun.

Afiliação

Sun SY; Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Hu XT; Institute of Acu-moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Yu XF; Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Zhang YY; Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Liu XH; Department of Experimental Pathology, College of Basic Medical Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
Liu YH; Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Wu SH; Department of Pathology, Hospital of Bin Zhou Medical College, Binzhou, China.
Li YY; Department of Pathology, Hospital of Bin Zhou Medical College, Binzhou, China.
Cui SX; Department of Pathology, Hospital of Bin Zhou Medical College, Binzhou, China.
Qu XJ; Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, China.

Br J Pharmacol ; 178(11): 2351-2369, 2021 06.

Article em En | MEDLINE | ID: mdl-33645631

Assuntos

Proteínas Adaptadoras de Transdução de Sinal; Proteína 5 Relacionada à Autofagia; Neoplasias Colorretais; Instabilidade de Microssatélites; Proteínas Adaptadoras de Transdução de Sinal/genética; Animais; Neoplasias Encefálicas; Proteínas Cromossômicas não Histona; Neoplasias Colorretais/tratamento farmacológico; Neoplasias Colorretais/genética; DNA; Metilação de DNA; Humanos; Camundongos; Proteína 1 Homóloga a MutL/genética; Síndromes Neoplásicas Hereditárias

Palavras-chave

5-FU resistance; MMR-D/MSI; Mis18α; colorectal cancer; hypermethylation of MLH1 promoter CpG island; nuclear translocation of ATG5

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Proteínas Adaptadoras de Transdução de Sinal / Instabilidade de Microssatélites / Proteína 5 Relacionada à Autofagia Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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