Synergistic effect of antimicrobial peptide LL-37 and colistin combination against multidrug-resistant Escherichia coli isolates.
Future Microbiol
; 16: 221-227, 2021 03.
Article
em En
| MEDLINE
| ID: mdl-33646013
ABSTRACT
Overview The global spread of antibiotic resistance represents a serious threat for public health. Aim:
We evaluated the efficacy of the antimicrobial peptide LL-37 as antimicrobial agent against multidrug-resistant Escherichia coli.Results:
LL-37 showed good activity against mcr-1 carrying, extended spectrum ß-lactamase- and carbapenemase-producing E. coli (minimum inhibitory concentration, MIC, from 16 to 64 mg/l). Checkerboard assays demonstrated synergistic effect of LL-37/colistin combination against all tested strains, further confirmed by time-kill and post antibiotic effect assays. MIC and sub-MIC concentrations of LL-37 were able to reduce biofilm formation.Conclusion:
Our preliminary data indicated that LL-37/colistin combination was effective against multidrug-resistant E. coli strains and suggested a new possible clinical application.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colistina
/
Peptídeos Catiônicos Antimicrobianos
/
Escherichia coli
/
Infecções por Escherichia coli
/
Antibacterianos
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article