Nanostructured zinc oxide film amalgamated with functionalized carbon nanotubes for facile electrochemical determination of nifedipine.

ABSTRACT

An innovative approach has been employed for the detection of nifedipine at glassy carbon electrode fabricated with zinc oxide nanoparticles embedded on functionalized multi walled carbon nanotubes. Herein, square wave voltammetry being an expeditious electrochemical technique has been utilized for the first time for the determination of nifedipine. Instrumental variables were altered to acquire optimized operational parameters. The electrochemical oxidation peak of nifedipine was procured at ∼ 807 mV which was recorded versus Ag/AgCl reference electrode. The oxidation peak was used to quantify the analyte in the dynamic linear range of 1 nM to 40 µM with highest sensitivity and lowest detection limit of 21.8 µA µM-1 and 0.49 nM respectively. The influence of common physiological interferents on the current signal of the analyte was examined. Pronounced stability and reproducibility of fabricated sensor was attained by the neoteric electrochemical approach. The developed protocol was efficaciously applied to quantify nifedipine in pharmaceutical formulations. The urine and blood serum sample of patients being treated for hypertension was effectively detected with nifedipine for the first time. The biological sample assay without the interference of the metabolites coexisting in the samples outlined the insight of selectivity of the developed sensor.