Desorption Electrospray Ionization Mass Spectrometry Imaging of Cimbi-36, a 5-HT<sub>2A</sub> Receptor Agonist, with Direct Comparison to Autoradiography and Positron Emission Tomography.

Jacobsen, Sophie C; Speth, Nikolaj R; Xiong, Mengfei; Herth, Matthias M; Kristensen, Jesper L; Palner, Mikael; Janfelt, Christian

Desorption Electrospray Ionization Mass Spectrometry Imaging of Cimbi-36, a 5-HT_2A Receptor Agonist, with Direct Comparison to Autoradiography and Positron Emission Tomography.

Jacobsen, Sophie C; Speth, Nikolaj R; Xiong, Mengfei; Herth, Matthias M; Kristensen, Jesper L; Palner, Mikael; Janfelt, Christian.

Afiliação

Jacobsen SC; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark.
Speth NR; Neurobiology Research Unit, Copenhagen University Hospital, Blegdamsvej 9, 2200, Copenhagen, Denmark.
Xiong M; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark.
Herth MM; Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital, Blegdamsvej 9, 2200, Copenhagen, Denmark.
Kristensen JL; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark.
Palner M; Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital, Blegdamsvej 9, 2200, Copenhagen, Denmark.
Janfelt C; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark.

Mol Imaging Biol ; 23(5): 676-685, 2021 10.

Article em En | MEDLINE | ID: mdl-33651266

Assuntos

Benzilaminas; Imagem Molecular/métodos; Fenetilaminas; Agonistas do Receptor 5-HT2 de Serotonina; Espectrometria de Massas por Ionização por Electrospray/métodos; Animais; Autorradiografia; Benzilaminas/química; Benzilaminas/farmacocinética; Encéfalo/diagnóstico por imagem; Encéfalo/metabolismo; Feminino; Fenetilaminas/química; Fenetilaminas/farmacocinética; Tomografia por Emissão de Pósitrons; Ratos Long-Evans; Agonistas do Receptor 5-HT2 de Serotonina/química; Agonistas do Receptor 5-HT2 de Serotonina/farmacocinética; Distribuição Tecidual

Palavras-chave

5-HT2A receptor agonist; Autoradiography; DESI-MSI; Mass spectrometry imaging; PET ligands; Rat brain

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenetilaminas / Benzilaminas / Espectrometria de Massas por Ionização por Electrospray / Imagem Molecular / Agonistas do Receptor 5-HT2 de Serotonina Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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