Activation of soluble guanylyl cyclase signalling with cinaciguat improves impaired kidney function in diabetic mice.

Harloff, Manuela; Prüschenk, Sally; Seifert, Roland; Schlossmann, Jens

Harloff, Manuela; Prüschenk, Sally; Seifert, Roland; Schlossmann, Jens.

Afiliação

Harloff M; Institute of Pharmacy, Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany.
Prüschenk S; Institute of Pharmacy, Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany.
Seifert R; Institute of Pharmacology, Hannover Medical School, Hannover, Germany.
Schlossmann J; Research Core Unit Metabolomics, Hannover Medical School, Hannover, Germany.

Br J Pharmacol ; 179(11): 2460-2475, 2022 06.

Article em En | MEDLINE | ID: mdl-33651375

Assuntos

Diabetes Mellitus Experimental; Diabetes Mellitus Tipo 1; Nefropatias Diabéticas; Animais; Benzoatos; GMP Cíclico/metabolismo; Diabetes Mellitus Experimental/tratamento farmacológico; Nefropatias Diabéticas/tratamento farmacológico; Feminino; Guanilato Ciclase/metabolismo; Humanos; Rim/metabolismo; Masculino; Camundongos; Óxido Nítrico/metabolismo; Guanilil Ciclase Solúvel/metabolismo

Palavras-chave

PKG; cGMP; cinaciguat; diabetic nephropathy; mesangial cells; sGC activator

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 1 / Nefropatias Diabéticas Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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