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Neddylation stabilizes Nav1.1 to maintain interneuron excitability and prevent seizures in murine epilepsy models.
Chen, Wenbing; Luo, Bin; Gao, Nannan; Li, Haiwen; Wang, Hongsheng; Li, Lei; Cui, Wanpeng; Zhang, Lei; Sun, Dong; Liu, Fang; Dong, Zhaoqi; Ren, Xiao; Zhang, Hongsheng; Su, Huabo; Xiong, Wen-Cheng; Mei, Lin.
Afiliação
  • Chen W; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Luo B; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Gao N; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Li H; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Wang H; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Li L; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Cui W; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
  • Zhang L; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Sun D; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Liu F; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Dong Z; Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
  • Ren X; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Zhang H; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Su H; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Xiong WC; Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
  • Mei L; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
J Clin Invest ; 131(8)2021 04 15.
Article em En | MEDLINE | ID: mdl-33651714
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Convulsões / Potenciais de Ação / Epilepsia / Canal de Sódio Disparado por Voltagem NAV1.1 / Interneurônios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Convulsões / Potenciais de Ação / Epilepsia / Canal de Sódio Disparado por Voltagem NAV1.1 / Interneurônios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article