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Identified lung adenocarcinoma metabolic phenotypes and their association with tumor immune microenvironment.
Wu, Xian-Ning; Su, Dan; Mei, Yi-De; Xu, Mei-Qing; Zhang, Hao; Wang, Ze-Yu; Li, Li-Ling; Peng, Li; Jiang, Jun-Yi; Yang, Jia-Yi; Li, Dong-Jie; Cao, Hui; Xia, Zhi-Wei; Zeng, Wen-Jing; Cheng, Quan; Zhang, Nan.
Afiliação
  • Wu XN; Department of Thoracic Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, People's Republic of China.
  • Su D; School of Nursing, Anhui Medical University, Hefei, People's Republic of China.
  • Mei YD; School of Life Sciences, University of Science and Technology of China (USTC), Hefei, 230027, Anhui, People's Republic of China.
  • Xu MQ; Department of Thoracic Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, People's Republic of China.
  • Zhang H; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.
  • Wang ZY; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.
  • Li LL; Department of Pathology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
  • Peng L; Department of Pathology, Xiangya Medical School, Central South University, Changsha, People's Republic of China.
  • Jiang JY; Department of Ophthalmology, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, People's Republic of China.
  • Yang JY; Aier School of Ophthalmology, Central South University, Changsha, People's Republic of China.
  • Li DJ; Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
  • Cao H; Department of Clinical Pharmacology, and Geriatric Urology, Xiangya International Medical Center, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
  • Xia ZW; National Clinical Research Center for Geriatric Disorders, Changsha, People's Republic of China.
  • Zeng WJ; Department of Psychiatry, The Second People's Hospital of Hunan Province, The Hospital of Hunan University of Chinese Medicine, Changsha, People's Republic of China.
  • Cheng Q; Department of Neurology, Hunan Aerospace Hospital, Changsha, People's Republic of China.
  • Zhang N; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Cancer Immunol Immunother ; 70(10): 2835-2850, 2021 Oct.
Article em En | MEDLINE | ID: mdl-33659999
BACKGROUND: Lung adenocarcinoma (LUAD), a subtype of non-small cell lung cancer (NSCLC), causes high mortality around the world. Previous studies have suggested that the metabolic pattern of tumor is associated with tumor response to immunotherapy and patient's survival outcome. Yet, this relationship in LUAD is still unknown. METHODS: Therefore, in this study, we identified the immune landscape in different tumor subtypes classified by metabolism-related genes expression with a large-scale dataset (tumor samples, n = 2181; normal samples, n = 419). We comprehensively correlated metabolism-related phenotypes with diverse clinicopathologic characteristics, genomic features, and immunotherapeutic efficacy in LUAD patients. RESULTS: And we confirmed tumors with activated lipid metabolism tend to have higher immunocytes infiltration and better response to checkpoint immunotherapy. This work highlights the connection between the metabolic pattern of tumor and tumor immune infiltration in LUAD. A scoring system based on metabolism-related gene expression is not only able to predict prognosis of patient with LUAD but also applied to pan-cancer. LUAD response to checkpoint immunotherapy can also be predicted by this scoring system. CONCLUSIONS: This work revealed the significant connection between metabolic pattern of tumor and tumor immune infiltration, regulating LUAD patients' response to immunotherapy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Adenocarcinoma de Pulmão / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Adenocarcinoma de Pulmão / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article