Cardiovascular risk factors and illicit drug use may have a more profound effect on coronary atherosclerosis progression in people living with HIV.
Eur Radiol
; 31(5): 2756-2767, 2021 May.
Article
em En
| MEDLINE
| ID: mdl-33660033
ABSTRACT
OBJECTIVES:
To assess whether HIV infection directly or indirectly promotes coronary artery disease (CAD) volume progression in a longitudinal study of African Americans.METHODS:
We randomly selected 300 individuals with subclinical CAD (210 male; age 48.0 ± 7.2 years; 226 HIV infected, 174 cocaine users) from 1429 cardiovascularly asymptomatic participants of a prospective epidemiological study between May 2004 and August 2015. Individuals underwent coronary CT angiography at two time points (mean follow-up 4.0 ± 2.3 years). We quantified noncalcified (NCP -100-350HU), low-attenuation noncalcified (LA-NCP -100-30HU), and calcified (CP ≥ 351 HU) plaque volumes. Linear mixed models were used to assess the effects of HIV infection, atherosclerotic cardiovascular disease (ASCVD) risk, and years of cocaine use on plaque volumes.RESULTS:
There was no significant difference in annual progression rates between HIV-infected and HIV-uninfected regarding NCP (8.7 [IQR 3.0-19.4] mm3/year vs. 4.9 [IQR 1.5-18.3] mm3/year, p = 0.14), LA-NCP (0.2 [IQR 0.0-1.6] mm3/year vs. 0.2 [IQR 0.0-0.9] mm3/year, p = 0.07) or CP volumes (0.3 [IQR 0.0-3.4] mm3/year vs. 0.1 [IQR 0.0-3.2] mm3/year, p = 0.30). Multivariately, HIV infection was not associated with NCP (-6.9mm3, CI [-32.8-19.0], p = 0.60), LA-NCP (-0.1mm3, CI [-2.6-2.4], p = 0.92), or CP volumes (-0.3mm3, CI [-9.3-8.6], p = 0.96). However, each percentage of ASCVD and each year of cocaine use significantly increased total, NCP, and CP volumes among HIV-infected individuals, but not among HIV-uninfected. Importantly, none of the HIV-associated medications had any effect on plaque volumes (p > 0.05 for all).CONCLUSIONS:
The more profound adverse effect of risk factors in HIV-infected individuals may explain the accelerated progression of CAD in these people, as HIV infection was not independently associated with any coronary plaque volume. KEY POINTS ⢠Human immunodeficiency virus-infected individuals may have similar subclinical coronary artery disease, as the infection is not independently associated with coronary plaque volumes. ⢠However, cardiovascular risk factors and illicit drug use may have a more profound effect on atherosclerosis progression in those with human immunodeficiency virus infection, which may explain the accelerated progression of CAD in these people. ⢠Nevertheless, through rigorous prevention and abstinence from illicit drugs, these individuals may experience similar cardiovascular outcomes as -uninfected individuals.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
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Doenças Cardiovasculares
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Drogas Ilícitas
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Infecções por HIV
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Placa Aterosclerótica
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article