Genetic factors involved in human G gamma and A gamma globin gene expression.
Eur J Haematol
; 40(4): 350-4, 1988 Apr.
Article
em En
| MEDLINE
| ID: mdl-3366225
ABSTRACT
G gamma to A gamma globin ratios, haplotypes at the beta globin gene cluster and the C----T substitution at -158 5' to the G gamma globin gene were studied in three Algerian families that include SS or S-beta(0) thal patients. G gamma to A gamma ratios were found similar, within a family, in subjects displaying the same combination of chromosomes 11, the ratio observed for a given combination depending on the chromosome haplotypes. Our data can be explained by the existence of several alleles of a genetic factor closely linked to the beta globin gene cluster and involved in the determination of G gamma to A gamma globin ratio.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Globinas
Limite:
Humans
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article