Transcriptome and chromatin landscape of iNKT cells are shaped by subset differentiation and antigen exposure.
Nat Commun
; 12(1): 1446, 2021 03 04.
Article
em En
| MEDLINE
| ID: mdl-33664261
ABSTRACT
Invariant natural killer T cells (iNKT cells) differentiate into thymic and peripheral NKT1, NKT2 and NKT17 subsets. Here we use RNA-seq and ATAC-seq analyses and show iNKT subsets are similar, regardless of tissue location. Lung iNKT cell subsets possess the most distinct location-specific features, shared with other innate lymphocytes in the lung, possibly consistent with increased activation. Following antigenic stimulation, iNKT cells undergo chromatin and transcriptional changes delineating two populations one similar to follicular helper T cells and the other NK or effector like. Phenotypic analysis indicates these changes are observed long-term, suggesting that iNKT cells gene programs are not fixed, but they are capable of chromatin remodeling after antigen to give rise to additional subsets.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Timo
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Subpopulações de Linfócitos T
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Células T Matadoras Naturais
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Células T Auxiliares Foliculares
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Pulmão
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article