Complexation with Random Methyl-ß-Cyclodextrin and (2-Hidroxypropyl)-ß-Cyclodextrin Enhances In Vivo Anti-Fibrotic and Anti-Inflammatory Effects of Chrysin via the Inhibition of NF-&#954;B and TGF-ß1/Smad Signaling Pathways and Modulation of Hepatic Pro/Anti-Fibrotic miRNA.

Ciceu, Alina; Balta, Cornel; Herman, Hidegard; Gharbia, Sami; Ignat, Simona-Rebeca; Dinescu, Sorina; Váradi, Judit; Fenyvesi, Ferenc; Gyöngyösi, Szilvia; Hermenean, Anca; Costache, Marieta

Complexation with Random Methyl-ß-Cyclodextrin and (2-Hidroxypropyl)-ß-Cyclodextrin Enhances In Vivo Anti-Fibrotic and Anti-Inflammatory Effects of Chrysin via the Inhibition of NF-κB and TGF-ß1/Smad Signaling Pathways and Modulation of Hepatic Pro/Anti-Fibrotic miRNA.

Ciceu, Alina; Balta, Cornel; Herman, Hidegard; Gharbia, Sami; Ignat, Simona-Rebeca; Dinescu, Sorina; Váradi, Judit; Fenyvesi, Ferenc; Gyöngyösi, Szilvia; Hermenean, Anca; Costache, Marieta.

Afiliação

Ciceu A; "Aurel Ardelean" Institute of Life Sciences, "Vasile GoldiÈ" Western University of Arad, 86 Revolution Str., 310048 Arad, Romania.
Balta C; Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, 050095 Bucharest, Romania.
Herman H; "Aurel Ardelean" Institute of Life Sciences, "Vasile GoldiÈ" Western University of Arad, 86 Revolution Str., 310048 Arad, Romania.
Gharbia S; "Aurel Ardelean" Institute of Life Sciences, "Vasile GoldiÈ" Western University of Arad, 86 Revolution Str., 310048 Arad, Romania.
Ignat SR; "Aurel Ardelean" Institute of Life Sciences, "Vasile GoldiÈ" Western University of Arad, 86 Revolution Str., 310048 Arad, Romania.
Dinescu S; Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, 050095 Bucharest, Romania.
Váradi J; Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, 050095 Bucharest, Romania.
Fenyvesi F; Research Institute of the University of Bucharest, Splaiul Independentei 91-95, 050095 Bucharest, Romania.
Gyöngyösi S; Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, Hungary.
Hermenean A; Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, Hungary.
Costache M; Department of Solid State Physics, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary.

Int J Mol Sci ; 22(4)2021 Feb 13.

Article em En | MEDLINE | ID: mdl-33668543

Assuntos

Flavonoides/farmacologia; Cirrose Hepática; MicroRNAs/biossíntese; NF-kappa B/metabolismo; Transdução de Sinais/efeitos dos fármacos; Proteínas Smad/metabolismo; Fator de Crescimento Transformador beta1/metabolismo; beta-Ciclodextrinas/farmacologia; Animais; Cirrose Hepática/tratamento farmacológico; Cirrose Hepática/genética; Cirrose Hepática/metabolismo; Cirrose Hepática/patologia; Masculino; Camundongos; MicroRNAs/genética; NF-kappa B/genética; Transdução de Sinais/genética; Proteínas Smad/genética; Fator de Crescimento Transformador beta1/genética

Palavras-chave

HPBCD; RAMEB; chrysin; fibrosis; inflammation; liver

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Transdução de Sinais / NF-kappa B / MicroRNAs / Beta-Ciclodextrinas / Proteínas Smad / Fator de Crescimento Transformador beta1 / Cirrose Hepática Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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