A LAT-Based Signaling Complex in the Immunological Synapse as Determined with Live Cell Imaging Is Less Stable in T Cells with Regulatory Capability.

Li, Yikui; Tunbridge, Helen M; Britton, Graham J; Hill, Elaine V; Sinai, Parisa; Cirillo, Silvia; Thompson, Clare; Fallah-Arani, Farnaz; Dovedi, Simon J; Wraith, David C; Wülfing, Christoph

Li, Yikui; Tunbridge, Helen M; Britton, Graham J; Hill, Elaine V; Sinai, Parisa; Cirillo, Silvia; Thompson, Clare; Fallah-Arani, Farnaz; Dovedi, Simon J; Wraith, David C; Wülfing, Christoph.

Afiliação

Li Y; School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK.
Tunbridge HM; School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK.
Britton GJ; School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK.
Hill EV; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Sinai P; School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK.
Cirillo S; School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK.
Thompson C; School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK.
Fallah-Arani F; Immunology Therapeutic Area, UCB, Slough, SL1 3WE, UK.
Dovedi SJ; Immunology Therapeutic Area, UCB, Slough, SL1 3WE, UK.
Wraith DC; R&D Oncology, AstraZeneca, Granta Park, Cambridge, CB21 6GH, UK.
Wülfing C; School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK.

Cells ; 10(2)2021 02 17.

Article em En | MEDLINE | ID: mdl-33671236

Assuntos

Células Apresentadoras de Antígenos/imunologia; Sinapses Imunológicas/imunologia; Ativação Linfocitária/imunologia; Receptores de Antígenos de Linfócitos T/metabolismo; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Animais; Camundongos Transgênicos; Receptores de Antígenos de Linfócitos T/imunologia; Transdução de Sinais/imunologia; Linfócitos T Reguladores/imunologia

Palavras-chave

CTLA-4; PD-1; central supramolecular activation cluster (cSMAC); immunological synapse; inhibitory receptors; linker for activation of T cells (LAT); regulatory T cell; supramolecular signaling complex; tolerance

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Receptores de Antígenos de Linfócitos T / Sinapses Imunológicas / Células Apresentadoras de Antígenos Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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