A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-&#945; Release in Human Lymphoblasts.

Li, Tianxia; Ning, Bo; Kong, Lingbo; Dai, Bingling; He, Xiaofei; Thomas, Joseph M; Sawa, Akira; Ross, Christopher A; Smith, Wanli W

A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-α Release in Human Lymphoblasts.

Li, Tianxia; Ning, Bo; Kong, Lingbo; Dai, Bingling; He, Xiaofei; Thomas, Joseph M; Sawa, Akira; Ross, Christopher A; Smith, Wanli W.

Afiliação

Li T; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Ning B; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
Kong L; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Dai B; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
He X; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
Thomas JM; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Sawa A; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Ross CA; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
Smith WW; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Cells ; 10(2)2021 02 23.

Article em En | MEDLINE | ID: mdl-33672296

Assuntos

Guanosina Trifosfato/metabolismo; Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina/metabolismo; Lipopolissacarídeos/farmacologia; Linfócitos/metabolismo; Transdução de Sinais; Fator de Necrose Tumoral alfa/metabolismo; Ativação Enzimática/efeitos dos fármacos; Células HEK293; Humanos; Linfócitos/efeitos dos fármacos; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Modelos Biológicos; Inibidor de NF-kappaB alfa/metabolismo; Fosforilação/efeitos dos fármacos; Ligação Proteica/efeitos dos fármacos; Fator 6 Associado a Receptor de TNF/metabolismo

Palavras-chave

GTP binding inhibitor; LPS; LRRK2; Parkinson's disease; TNF-α; lymphoblast

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos / Transdução de Sinais / Lipopolissacarídeos / Fator de Necrose Tumoral alfa / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina / Guanosina Trifosfato Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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