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Development of isatin-thiazolo[3,2-a]benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and molecular dynamics investigations.
Eldehna, Wagdy M; El Hassab, Mahmoud A; Abo-Ashour, Mahmoud F; Al-Warhi, Tarfah; Elaasser, Mahmoud M; Safwat, Nesreen A; Suliman, Howayda; Ahmed, Marwa F; Al-Rashood, Sara T; Abdel-Aziz, Hatem A; El-Haggar, Radwan.
Afiliação
  • Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh P.O. Box 33516, Egypt. Electronic address: wagdy2000@gmail.com.
  • El Hassab MA; Department of Pharmaceutical Chemistry, School of Pharmacy, Badr University in Cairo, Badr City 11829, Cairo, Egypt.
  • Abo-Ashour MF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, Egypt.
  • Al-Warhi T; Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
  • Elaasser MM; The Regional Center for Mycology and Biotechnology, Al-Azhar University, Cairo, Egypt.
  • Safwat NA; The Regional Center for Mycology and Biotechnology, Al-Azhar University, Cairo, Egypt.
  • Suliman H; Department of Medical Biochemistry, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
  • Ahmed MF; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, 11795 Cairo, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Taif University, Taif 21974, Saudi Arabia.
  • Al-Rashood ST; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
  • Abdel-Aziz HA; Department of Applied Organic Chemistry, National Research Center, Dokki, Giza P.O. Box 12622, Egypt.
  • El-Haggar R; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, 11795 Cairo, Egypt.
Bioorg Chem ; 110: 104748, 2021 05.
Article em En | MEDLINE | ID: mdl-33684714
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzimidazóis / Quinase 2 Dependente de Ciclina / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzimidazóis / Quinase 2 Dependente de Ciclina / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article