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Pharmacological targeting of host chaperones protects from pertussis toxin in vitro and in vivo.
Ernst, Katharina; Mittler, Ann-Katrin; Winkelmann, Veronika; Kling, Carolin; Eberhardt, Nina; Anastasia, Anna; Sonnabend, Michael; Lochbaum, Robin; Wirsching, Jan; Sakari, Moona; Pulliainen, Arto T; Skerry, Ciaran; Carbonetti, Nicholas H; Frick, Manfred; Barth, Holger.
Afiliação
  • Ernst K; Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Ulm, Germany. katharina.ernst@uni-ulm.de.
  • Mittler AK; Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Ulm, Germany.
  • Winkelmann V; Institute of General Physiology, University of Ulm, Ulm, Germany.
  • Kling C; Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Ulm, Germany.
  • Eberhardt N; Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Ulm, Germany.
  • Anastasia A; Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Ulm, Germany.
  • Sonnabend M; Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Ulm, Germany.
  • Lochbaum R; Institute of General Physiology, University of Ulm, Ulm, Germany.
  • Wirsching J; Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Ulm, Germany.
  • Sakari M; Institute of Biomedicine, Research Unit for Infection and Immunity, University of Turku, Turku, Finland.
  • Pulliainen AT; Institute of Biomedicine, Research Unit for Infection and Immunity, University of Turku, Turku, Finland.
  • Skerry C; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Carbonetti NH; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Frick M; Institute of General Physiology, University of Ulm, Ulm, Germany.
  • Barth H; Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Ulm, Germany. holger.barth@uni-ulm.de.
Sci Rep ; 11(1): 5429, 2021 03 08.
Article em En | MEDLINE | ID: mdl-33686161
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bordetella pertussis / Sistemas de Liberação de Medicamentos / Chaperonas Moleculares / Toxina Pertussis / Inibidores Enzimáticos / Células Epiteliais / Leucocitose Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bordetella pertussis / Sistemas de Liberação de Medicamentos / Chaperonas Moleculares / Toxina Pertussis / Inibidores Enzimáticos / Células Epiteliais / Leucocitose Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article