Your browser doesn't support javascript.
loading
Genomic insights into the host specific adaptation of the Pneumocystis genus.
Cissé, Ousmane H; Ma, Liang; Dekker, John P; Khil, Pavel P; Youn, Jung-Ho; Brenchley, Jason M; Blair, Robert; Pahar, Bapi; Chabé, Magali; Van Rompay, Koen K A; Keesler, Rebekah; Sukura, Antti; Hirsch, Vanessa; Kutty, Geetha; Liu, Yueqin; Peng, Li; Chen, Jie; Song, Jun; Weissenbacher-Lang, Christiane; Xu, Jie; Upham, Nathan S; Stajich, Jason E; Cuomo, Christina A; Cushion, Melanie T; Kovacs, Joseph A.
Afiliação
  • Cissé OH; Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health (NIH), Bethesda, MD, USA. ousmane.cisse@nih.gov.
  • Ma L; Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health (NIH), Bethesda, MD, USA. mal3@nih.gov.
  • Dekker JP; Bacterial Pathogenesis and Antimicrobial Resistance Unit, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, USA.
  • Khil PP; Department of Laboratory Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, MD, USA.
  • Youn JH; Bacterial Pathogenesis and Antimicrobial Resistance Unit, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, USA.
  • Brenchley JM; Department of Laboratory Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, MD, USA.
  • Blair R; Department of Laboratory Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, MD, USA.
  • Pahar B; Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD, USA.
  • Chabé M; Tulane National Primate Research Center, Tulane University, New Orleans, LA, USA.
  • Van Rompay KKA; Tulane National Primate Research Center, Tulane University, New Orleans, LA, USA.
  • Keesler R; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Centre d'Infection et d'Immunité de Lille, Lille, France.
  • Sukura A; California National Primate Research Center, University of California, Davis, CA, USA.
  • Hirsch V; California National Primate Research Center, University of California, Davis, CA, USA.
  • Kutty G; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
  • Liu Y; Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, MD, USA.
  • Peng L; Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health (NIH), Bethesda, MD, USA.
  • Chen J; Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health (NIH), Bethesda, MD, USA.
  • Song J; Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Weissenbacher-Lang C; Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Xu J; Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical Center, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Upham NS; Institute of Pathology, Department of Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.
  • Stajich JE; Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical Center, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Cuomo CA; Arizona State University, School of Life Sciences, Tempe, ARI, USA.
  • Cushion MT; Department of Microbiology and Plant Pathology and Institute for Integrative Genome Biology, University of California, Riverside, Riverside-California, Riverside, CA, USA.
  • Kovacs JA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.
Commun Biol ; 4(1): 305, 2021 03 08.
Article em En | MEDLINE | ID: mdl-33686174
ABSTRACT
Pneumocystis jirovecii, the fungal agent of human Pneumocystis pneumonia, is closely related to macaque Pneumocystis. Little is known about other Pneumocystis species in distantly related mammals, none of which are capable of establishing infection in humans. The molecular basis of host specificity in Pneumocystis remains unknown as experiments are limited due to an inability to culture any species in vitro. To explore Pneumocystis evolutionary adaptations, we have sequenced the genomes of species infecting macaques, rabbits, dogs and rats and compared them to available genomes of species infecting humans, mice and rats. Complete whole genome sequence data enables analysis and robust phylogeny, identification of important genetic features of the host adaptation, and estimation of speciation timing relative to the rise of their mammalian hosts. Our data reveals insights into the evolution of P. jirovecii, the sole member of the genus able to infect humans.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia por Pneumocystis / Proteínas Fúngicas / Genoma Fúngico / Evolução Molecular / Pneumocystis carinii Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia por Pneumocystis / Proteínas Fúngicas / Genoma Fúngico / Evolução Molecular / Pneumocystis carinii Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article