Neoadjuvant chemoradiation alters biomarkers of anticancer immunotherapy responses in locally advanced rectal cancer.

Seo, Incheol; Lee, Hye Won; Byun, Sang Jun; Park, Jee Young; Min, Hyeonji; Lee, Sung Hwan; Lee, Ju-Seog; Kim, Shin; Bae, Sung Uk

Seo, Incheol; Lee, Hye Won; Byun, Sang Jun; Park, Jee Young; Min, Hyeonji; Lee, Sung Hwan; Lee, Ju-Seog; Kim, Shin; Bae, Sung Uk.

Afiliação

Seo I; Department of Microbiology, Dongguk University College of Medicine, Gyeongju, Gyeongsangbuk-do, Korea (the Republic of).
Lee HW; Department of Pathology, Keimyung University Dongsan Medical Center, Daegu, Korea (the Republic of).
Byun SJ; Institute for Cancer Research, Keimyung University, Daegu, Korea (the Republic of).
Park JY; Department of Radiation Oncology, Keimyung University School of Medicine, Daegu, Korea (the Republic of).
Min H; Department of Pathology, Keimyung University Dongsan Medical Center, Daegu, Korea (the Republic of).
Lee SH; Department of Immunology, Keimyung University School of Medicine, Daegu, Korea (the Republic of).
Lee JS; Department of Immunology, Keimyung University School of Medicine, Daegu, Korea (the Republic of).
Kim S; Department of Surgery, CHA University - Bundang Campus, Seongnam, Gyeonggi-do, Korea (the Republic of).
Bae SU; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

J Immunother Cancer ; 9(3)2021 03.

Article em En | MEDLINE | ID: mdl-33692216

Assuntos

Adenocarcinoma/terapia; Biomarcadores Tumorais/genética; Quimiorradioterapia Adjuvante; Terapia Neoadjuvante; Neoplasias Retais/terapia; Microambiente Tumoral/imunologia; Adenocarcinoma/genética; Adenocarcinoma/imunologia; Adenocarcinoma/patologia; Bases de Dados Genéticas; Perfilação da Expressão Gênica; Regulação Neoplásica da Expressão Gênica; Redes Reguladoras de Genes; Células HCT116; Humanos; RNA-Seq; Neoplasias Retais/genética; Neoplasias Retais/imunologia; Neoplasias Retais/patologia; Fatores de Tempo; Transcriptoma; Resultado do Tratamento

Palavras-chave

gene expression profiling; genome instability; immunomodulation; radioimmunotherapy; radiotherapy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retais / Adenocarcinoma / Biomarcadores Tumorais / Terapia Neoadjuvante / Microambiente Tumoral / Quimiorradioterapia Adjuvante Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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