Mechanisms of damage tolerance and repair during DNA replication.
Nucleic Acids Res
; 49(6): 3033-3047, 2021 04 06.
Article
em En
| MEDLINE
| ID: mdl-33693881
ABSTRACT
Accurate duplication of chromosomal DNA is essential for the transmission of genetic information. The DNA replication fork encounters template lesions, physical barriers, transcriptional machinery, and topological barriers that challenge the faithful completion of the replication process. The flexibility of replisomes coupled with tolerance and repair mechanisms counteract these replication fork obstacles. The cell possesses several universal mechanisms that may be activated in response to various replication fork impediments, but it has also evolved ways to counter specific obstacles. In this review, we will discuss these general and specific strategies to counteract different forms of replication associated damage to maintain genomic stability.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
Reparo do DNA
/
Replicação do DNA
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article