TRIM32 inhibits the proliferation and migration of pulmonary artery smooth muscle cells through the inactivation of PI3K/Akt pathway in pulmonary arterial hypertension.

Hu, Zhi; Song, Qiang; Ma, Hui; Guo, Yaozhang; Zhang, Tingting; Xie, Hang; Luo, Xiaohui

Hu, Zhi; Song, Qiang; Ma, Hui; Guo, Yaozhang; Zhang, Tingting; Xie, Hang; Luo, Xiaohui.

Afiliação

Hu Z; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road, Xi'an, Shaanxi, 710061, China. huzhi03@163.com.
Song Q; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road, Xi'an, Shaanxi, 710061, China.
Ma H; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road, Xi'an, Shaanxi, 710061, China.
Guo Y; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road, Xi'an, Shaanxi, 710061, China.
Zhang T; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road, Xi'an, Shaanxi, 710061, China.
Xie H; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road, Xi'an, Shaanxi, 710061, China.
Luo X; Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road, Xi'an, Shaanxi, 710061, China.

J Bioenerg Biomembr ; 53(3): 309-320, 2021 06.

Article em En | MEDLINE | ID: mdl-33694017

Assuntos

Miócitos de Músculo Liso/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Hipertensão Arterial Pulmonar/genética; Fatores de Transcrição/metabolismo; Proteínas com Motivo Tripartido/metabolismo; Ubiquitina-Proteína Ligases/metabolismo; Animais; Apoptose/fisiologia; Movimento Celular/fisiologia; Proliferação de Células/fisiologia; Humanos; Masculino; Hipertensão Arterial Pulmonar/fisiopatologia; Transfecção

Palavras-chave

Hypoxia; Migration; Proliferation; Pulmonary arterial hypertension (PAH); Pulmonary artery smooth muscle cells (PASMCs); TRIM32

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Fosfatidilinositol 3-Quinases / Miócitos de Músculo Liso / Ubiquitina-Proteína Ligases / Proteínas Proto-Oncogênicas c-akt / Proteínas com Motivo Tripartido / Hipertensão Arterial Pulmonar Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google