Glycan structure-based perspectives on the entry and release of glycoproteins in the calnexin/calreticulin cycle.
Carbohydr Res
; 502: 108273, 2021 Apr.
Article
em En
| MEDLINE
| ID: mdl-33713911
ABSTRACT
N-glycans are attached to newly synthesised polypeptides and are involved in the folding, secretion, and degradation of N-linked glycoproteins. In particular, the calnexin/calreticulin cycle, which is the central mechanism of the entry and release of N-linked glycoproteins depending on the folding sates, has been well studied. In addition to biological studies on the calnexin/calreticulin cycle, several studies have revealed complementary roles of in vitro chemistry-based research in the structure-based understanding of the cycle. In this mini-review, we summarise chemistry-based results and highlight their importance for further understanding of the cycle.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
/
Glicoproteínas
/
Calnexina
/
Calreticulina
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article