Urinary phthalate metabolite concentrations and hot flashes in women from an urban convenience sample of midlife women.
Environ Res
; 197: 110891, 2021 06.
Article
em En
| MEDLINE
| ID: mdl-33722529
ABSTRACT
CONTEXT Phthalate exposure is associated with altered reproductive function, but little is known about associations of phthalate exposure with risk of hot flashes. OBJECTIVE:
To investigate associations of urinary phthalate metabolite levels with four hot flash outcomes in midlife women.DESIGN:
A cross-sectional study of the first year of a prospective cohort of midlife women, the Midlife Women's Health Study (2006-2015), a convenience sample from an urban setting.PARTICIPANTS:
728 multi-racial/ethnic pre- and perimenopausal women aged 45-54 years. OUTCOMEMEASURES:
Women completed questionnaires about hot flash experience and provided 1-4 urine samples over four consecutive weeks that were pooled for analysis. Phthalate metabolites were assessed individually and as molar sums representative of common compounds (all phthalates Æ©Phthalates; DEHP Æ©DEHP), exposure sources (plastics Æ©Plastic; personal care products Æ©PCP), and modes of action (anti-androgenic Æ©AA). Covariate-adjusted logistic regression models were used to assess associations of continuous natural log-transformed phthalate metabolite concentrations with hot flash outcomes. Analyses were conducted to explore whether associations differed by menopause status, body mass index (BMI), race/ethnicity, and depressive symptoms.RESULTS:
Overall, 45% of women reported a history of hot flashes. Compared to women who never experienced hot flashes, every two-fold increase in Æ©Plastic was associated with 18% (OR 1.18; 95%CI 0.98, 1.43) and 38% (OR 1.38; 95%CI 1.11, 1.70) higher odds of experiencing hot flashes in the past 30 days and experiencing daily/weekly hot flashes, respectively. Some associations of phthalates with certain hot flash outcomes differed by menopause status, BMI, race/ethnicity, and depressive symptoms.CONCLUSIONS:
This study suggests that phthalates are associated with hot flash experience and may impact hot flash risk in women who are susceptible to experiencing hot flashes.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Menopausa
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Fogachos
Tipo de estudo:
Observational_studies
/
Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article