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Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm.
Dziedzicka, Dominika; Tewary, Mukul; Keller, Alexander; Tilleman, Laurentijn; Prochazka, Laura; Östblom, Joel; Couvreu De Deckersberg, Edouard; Markouli, Christina; Franck, Silvie; Van Nieuwerburgh, Filip; Spits, Claudia; Zandstra, Peter W; Sermon, Karen; Geens, Mieke.
Afiliação
  • Dziedzicka D; Research Group Reproduction and Genetics, Vrije Universiteit Brussel, 1090, Brussels, Belgium.
  • Tewary M; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3E1, Canada.
  • Keller A; Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, London, SE1 9RT, UK.
  • Tilleman L; Research Group Reproduction and Genetics, Vrije Universiteit Brussel, 1090, Brussels, Belgium.
  • Prochazka L; Laboratory of Pharmaceutical Biotechnology, Ghent University, 9000, Ghent, Belgium.
  • Östblom J; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3E1, Canada.
  • Couvreu De Deckersberg E; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3E1, Canada.
  • Markouli C; Research Group Reproduction and Genetics, Vrije Universiteit Brussel, 1090, Brussels, Belgium.
  • Franck S; Research Group Reproduction and Genetics, Vrije Universiteit Brussel, 1090, Brussels, Belgium.
  • Van Nieuwerburgh F; Research Group Reproduction and Genetics, Vrije Universiteit Brussel, 1090, Brussels, Belgium.
  • Spits C; Laboratory of Pharmaceutical Biotechnology, Ghent University, 9000, Ghent, Belgium.
  • Zandstra PW; Research Group Reproduction and Genetics, Vrije Universiteit Brussel, 1090, Brussels, Belgium.
  • Sermon K; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3E1, Canada.
  • Geens M; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
Sci Rep ; 11(1): 6137, 2021 03 17.
Article em En | MEDLINE | ID: mdl-33731744
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica no Desenvolvimento / Endoderma / Via de Sinalização Wnt / Células-Tronco Embrionárias Humanas Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica no Desenvolvimento / Endoderma / Via de Sinalização Wnt / Células-Tronco Embrionárias Humanas Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article