Synthesis, biological activities and docking studies of pleuromutilin derivatives with piperazinyl urea linkage.

Zhang, Yuanyuan; Xie, Chuan; Liu, Yang; Shang, Feng; Shao, Rushiya; Yu, Jing; Wu, Chunxia; Yao, Xinghui; Liu, Dongfang; Wang, Zhouyu

Zhang, Yuanyuan; Xie, Chuan; Liu, Yang; Shang, Feng; Shao, Rushiya; Yu, Jing; Wu, Chunxia; Yao, Xinghui; Liu, Dongfang; Wang, Zhouyu.

Afiliação

Zhang Y; Department of Chemistry, School of Science, Xihua University, Chengdu, China.
Xie C; Yibin Key Laboratory of Research and Application of Small Organic Chiral Molecules, Yibin Research Institute of Xihua University, Yibin, China.
Liu Y; Department of Chemistry, School of Science, Xihua University, Chengdu, China.
Shang F; Department of Chemistry, School of Science, Xihua University, Chengdu, China.
Shao R; Department of Chemistry, School of Science, Xihua University, Chengdu, China.
Yu J; Department of Chemistry, School of Science, Xihua University, Chengdu, China.
Wu C; Kampo Medicine Pharmacology Research Laboratory, Graduate School of Pharmaceutical Sciences, Yokohama University of Pharmacy, Yokohama-shi, Japan.
Yao X; Department of Chemistry, School of Science, Xihua University, Chengdu, China.
Liu D; Department of Chemistry, School of Science, Xihua University, Chengdu, China.
Wang Z; Department of Chemistry, School of Science, Xihua University, Chengdu, China.

J Enzyme Inhib Med Chem ; 36(1): 764-775, 2021 Dec.

Article em En | MEDLINE | ID: mdl-33733986

Assuntos

Antibacterianos/farmacologia; Diterpenos/farmacologia; Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos; Simulação de Acoplamento Molecular; Compostos Policíclicos/farmacologia; Ureia/farmacologia; Antibacterianos/síntese química; Antibacterianos/química; Diterpenos/síntese química; Diterpenos/química; Células HEK293; Humanos; Testes de Sensibilidade Microbiana; Estrutura Molecular; Compostos Policíclicos/síntese química; Compostos Policíclicos/química; Ureia/análogos & derivados; Ureia/química; Pleuromutilinas

Palavras-chave

MRSA; Pleuromutilin; biological activities; piperazinyl urea; synthesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Policíclicos / Ureia / Diterpenos / Staphylococcus aureus Resistente à Meticilina / Simulação de Acoplamento Molecular / Antibacterianos Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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