Polarised maintenance of cytoophidia in Drosophila follicle epithelia.
Exp Cell Res
; 402(2): 112564, 2021 05 15.
Article
em En
| MEDLINE
| ID: mdl-33737069
ABSTRACT
The metabolic enzyme CTP synthase (CTPS) can form filamentous structures named cytoophidia in numerous types of cells, including follicle cells. However, the regulation of cytoophidium assembly remains elusive. The apicobasal polarity, a defining characteristic of Drosophila follicle epithelium, is established and regulated by a variety of membrane domains. Here we show that CTPS can form cytoophidia in Drosophila epithelial follicle cells. Cytoophidia localise to the basolateral side of follicle cells. If apical polarity regulators are knocked down, cytoophidia become unstable and distribute abnormally. Knockdown of basolateral polarity regulators has no significant effect on cytoophidia, even though the polarity is disturbed. Our results indicate that cytoophidia are maintained via polarised distribution on the basolateral side of Drosophila follicle epithelia, which is primarily achieved through the apical polarity regulators.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polaridade Celular
/
Carbono-Nitrogênio Ligases
/
Epitélio
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Folículo Ovariano
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article