Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms.
J Infect Dis
; 225(6): 965-970, 2022 03 15.
Article
em En
| MEDLINE
| ID: mdl-33744954
ABSTRACT
Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in serum and cerebrospinal fluid (CSF) samples from 16 patients with coronavirus disease 2019 and neurological symptoms were assessed using 2 independent methods. Immunoglobulin G (IgG) specific for the virus spike protein was found in 81% of patients in serum and in 56% in CSF. SARS-CoV-2 IgG in CSF was observed in 2 patients with negative serological findings. Levels of IgG in both serum and CSF were associated with disease severity (Pâ
<â
.05). All patients with elevated markers of central nervous system damage in CSF also had CSF antibodies (Pâ
=â
.002), and CSF antibodies had the highest predictive value for neuronal damage markers of all tested clinical variables.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina G
/
SARS-CoV-2
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COVID-19
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Anticorpos Antivirais
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Doenças do Sistema Nervoso
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
/
Prognostic_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article