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18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) is accurate for high-grade prostate cancer bone staging when compared to bone scintigraphy.
Otis-Chapados, Samuel; Goulet, Cassandra Ringuette; Dubois, Gabriel; Lavallée, Étienne; Dujardin, Thierry; Fradet, Yves; Lacombe, Louis; Lodde, Michele; Tiguert, Rabi; Toren, Paul; Fradet, Vincent; Beauregard, Jean-Mathieu; Buteau, François-Alexandre; Pouliot, Frédéric.
Afiliação
  • Otis-Chapados S; Oncology Division, CHU de Québec Research Center, Quebec, QC, Canada.
  • Goulet CR; Department of Surgery, Faculty of Medicine, Laval University, Quebec, QC, Canada.
  • Dubois G; Oncology Division, CHU de Québec Research Center, Quebec, QC, Canada.
  • Lavallée É; Department of Surgery, Faculty of Medicine, Laval University, Quebec, QC, Canada.
  • Dujardin T; Oncology Division, CHU de Québec Research Center, Quebec, QC, Canada.
  • Fradet Y; Department of Surgery, Faculty of Medicine, Laval University, Quebec, QC, Canada.
  • Lodde M; Oncology Division, CHU de Québec Research Center, Quebec, QC, Canada.
  • Tiguert R; Department of Surgery, Faculty of Medicine, Laval University, Quebec, QC, Canada.
  • Toren P; Oncology Division, CHU de Québec Research Center, Quebec, QC, Canada.
  • Fradet V; Department of Surgery, Faculty of Medicine, Laval University, Quebec, QC, Canada.
  • Beauregard JM; Oncology Division, CHU de Québec Research Center, Quebec, QC, Canada.
  • Buteau FA; Department of Surgery, Faculty of Medicine, Laval University, Quebec, QC, Canada.
  • Pouliot F; Oncology Division, CHU de Québec Research Center, Quebec, QC, Canada.
Can Urol Assoc J ; 15(10): 301-307, 2021 Oct.
Article em En | MEDLINE | ID: mdl-33750523
INTRODUCTION: In this study, we compared 18F-fluorodeoxyglucose (18F-FDG)-positron emission tomography/computed tomography (PET/CT) and bone scintigraphy accuracies for the detection of bone metastases for primary staging in high-grade prostate cancer (PCa) patients to determine if 18F-FDG-PET/CT could be used alone as a staging modality. METHODS: Men with localized high-grade PCa (n=256, Gleason 8-10, International Society of Urological Pathology [ISUP] grades 4 or 5) were imaged with bone scintigraphy and 18F-FDG-PET/CT. We compared, on a per-patient basis, the accuracy of the two imaging modalities, taking inter-modality agreement as the standard of truth (SOT). RESULTS: 18F-FDG-PET/CT detected at least one bone metastasis in 33 patients compared to only 26 with bone scan. Of the seven false-negative bone scintigraphies, four (57.1%) were solitary metastases (monometastatic), three (42.9%) were oligometastatic (2-4 lesions), and none were plurimetastatic (>4 lesions). Compared to SOT, 18F-FDG-PET/CT showed higher sensitivity and accuracy than bone scintigraphy (100% vs. 78.8%, and 98.7% vs. 98.2%) for the detection of skeletal lesions. CONCLUSIONS: 18F-FDG-PET/CT appears similar or better than conventional bone scans to assess for bone metastases in patients newly diagnosed with high-grade PCa. Since intraprostatic FDG uptake is also a biomarker for failure of radical prostatectomy and that FDG-PET/CT has been shown to be accurate in detecting PCa lymph node metastasis, FDG-PET/CT has the potential to be used as the sole preoperative staging modality in high-grade PCa.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article