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Discovery and resistance mechanism of a selective CDK12 degrader.
Jiang, Baishan; Gao, Yang; Che, Jianwei; Lu, Wenchao; Kaltheuner, Ines H; Dries, Ruben; Kalocsay, Marian; Berberich, Matthew J; Jiang, Jie; You, Inchul; Kwiatkowski, Nicholas; Riching, Kristin M; Daniels, Danette L; Sorger, Peter K; Geyer, Matthias; Zhang, Tinghu; Gray, Nathanael S.
Afiliação
  • Jiang B; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Gao Y; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Che J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Lu W; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Kaltheuner IH; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Dries R; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Kalocsay M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Berberich MJ; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Jiang J; Institute of Structural Biology, University of Bonn, Bonn, Germany.
  • You I; Department of Hematology and Oncology, Boston University, Boston, MA, USA.
  • Kwiatkowski N; Department of Computational Medicine, Boston University, Boston, MA, USA.
  • Riching KM; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Daniels DL; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Sorger PK; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Geyer M; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Zhang T; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Gray NS; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Nat Chem Biol ; 17(6): 675-683, 2021 06.
Article em En | MEDLINE | ID: mdl-33753926
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinases Ciclina-Dependentes Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinases Ciclina-Dependentes Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article