Visualization of hydrogen atoms in a perdeuterated lectin-fucose complex reveals key details of protein-carbohydrate interactions.

Gajdos, Lukas; Blakeley, Matthew P; Kumar, Atul; Wimmerová, Michaela; Haertlein, Michael; Forsyth, V Trevor; Imberty, Anne; Devos, Juliette M

Gajdos, Lukas; Blakeley, Matthew P; Kumar, Atul; Wimmerová, Michaela; Haertlein, Michael; Forsyth, V Trevor; Imberty, Anne; Devos, Juliette M.

Afiliação

Gajdos L; Life Sciences Group, Institut Laue-Langevin, 38000 Grenoble, France; Partnership for Structural Biology (PSB), 38000 Grenoble, France; Université Grenoble Alpes, CNRS, CERMAV, 38000 Grenoble, France.
Blakeley MP; Large Scale Structures Group, Institut Laue-Langevin, 38000 Grenoble, France.
Kumar A; CEITEC, Masaryk University, 625 00 Brno, Czech Republic; NCBR, Faculty of Science, Masaryk University, 625 00 Brno, Czech Republic; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceské Budejovice, Czech Republic.
Wimmerová M; CEITEC, Masaryk University, 625 00 Brno, Czech Republic; NCBR, Faculty of Science, Masaryk University, 625 00 Brno, Czech Republic.
Haertlein M; Life Sciences Group, Institut Laue-Langevin, 38000 Grenoble, France; Partnership for Structural Biology (PSB), 38000 Grenoble, France.
Forsyth VT; Life Sciences Group, Institut Laue-Langevin, 38000 Grenoble, France; Partnership for Structural Biology (PSB), 38000 Grenoble, France; Faculty of Natural Sciences, Keele University, ST5 5BG Staffordshire, UK.
Imberty A; Université Grenoble Alpes, CNRS, CERMAV, 38000 Grenoble, France. Electronic address: anne.imberty@cermav.cnrs.fr.
Devos JM; Life Sciences Group, Institut Laue-Langevin, 38000 Grenoble, France; Partnership for Structural Biology (PSB), 38000 Grenoble, France. Electronic address: devosj@ill.fr.

Structure ; 29(9): 1003-1013.e4, 2021 09 02.

Article em En | MEDLINE | ID: mdl-33765407

Assuntos

Proteínas de Bactérias/química; Fucose/química; Lectinas/química; Proteínas de Bactérias/metabolismo; Fucose/metabolismo; Hidrogênio/química; Lectinas/metabolismo; Photorhabdus/química; Ligação Proteica

Palavras-chave

Photorhabdus; carbohydrate-binding; carbohydrates; fully deuterated L-fucose; lectin; ligand binding; neutron macromolecular crystallography (NMX); neutron structure; perdeuteration; stacking interaction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Fucose / Lectinas Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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