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SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition.
Mullen, Peter J; Garcia, Gustavo; Purkayastha, Arunima; Matulionis, Nedas; Schmid, Ernst W; Momcilovic, Milica; Sen, Chandani; Langerman, Justin; Ramaiah, Arunachalam; Shackelford, David B; Damoiseaux, Robert; French, Samuel W; Plath, Kathrin; Gomperts, Brigitte N; Arumugaswami, Vaithilingaraja; Christofk, Heather R.
Afiliação
  • Mullen PJ; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
  • Garcia G; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, USA.
  • Purkayastha A; UCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital UCLA, Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
  • Matulionis N; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
  • Schmid EW; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
  • Momcilovic M; Department of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
  • Sen C; UCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital UCLA, Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
  • Langerman J; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
  • Ramaiah A; Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA, USA.
  • Shackelford DB; Department of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
  • Damoiseaux R; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.
  • French SW; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, USA.
  • Plath K; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.
  • Gomperts BN; California Nanosystems Institute, UCLA, Los Angeles, CA, USA.
  • Arumugaswami V; Department of Bioengineering, UCLA Samueli School of Engineering, Los Angeles, CA, USA.
  • Christofk HR; Department of Molecular Biology Interdepartmental Program, UCLA, Los Angeles, CA, USA.
Nat Commun ; 12(1): 1876, 2021 03 25.
Article em En | MEDLINE | ID: mdl-33767183
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ciclo do Ácido Cítrico / Inibidores de Proteínas Quinases / Alvo Mecanístico do Complexo 1 de Rapamicina / COVID-19 Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ciclo do Ácido Cítrico / Inibidores de Proteínas Quinases / Alvo Mecanístico do Complexo 1 de Rapamicina / COVID-19 Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article