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Gallbladder cancer detected by elevated serum KL-6 levels during the follow-up of interstitial pneumonia: a case report.
Yonenaga, Yoshikuni; Kurosawa, Manabu; Higashide, Shunichi.
Afiliação
  • Yonenaga Y; Department of Surgery, Nagahama City Hospital, 313 Ooinui-cho, Nagahama, Shiga 526-8580 Japan.
  • Kurosawa M; Department of Surgery, Ako City Hospital, 1090 Nakahiro, Ako, Hyogo 678-0232 Japan.
  • Higashide S; Department of Diagnostic Pathology, Nagahama City Hospital, Nagahama, Shiga Japan.
Int Cancer Conf J ; 10(2): 119-126, 2021 Apr.
Article em En | MEDLINE | ID: mdl-33782643
Serum Krebs von den Lungen-6 (KL-6) is clinically used for the diagnosis of interstitial pneumonia (IP) as well as the evaluation of its disease activity. A female patient was diagnosed with idiopathic IP when she was 62 years old. Four years later, serum levels of KL-6 had been elevated gradually from 2400-3821 U/ml, and she was found to have gallbladder cancer detected by contrast-enhanced computed tomography (CT) and 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/CT. She thus underwent a radical extended cholecystectomy. After the operation, serum levels of KL-6 showed a steep decline to 590 U/ml. Immunohistological examination revealed that KL-6 presented in gallbladder cancer cells. Taken together, serum KL-6 was shown to be produced by gallbladder cancer cells. Here, we present the first patient in whom increased serum KL-6 levels led to the diagnosis of gallbladder cancer during follow-up of IP. When serum levels of KL-6 are elevated during the follow-up care of IP despite no worsening of IP, an examination of the whole body should be performed to find possibly existing malignant tumors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article