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Prognostic Impact of Albumin-bilirubin (ALBI) Grade on Non-small Lung Cell Carcinoma: A Propensity-score Matched Analysis.
Kinoshita, Fumihiko; Yamashita, Takanori; Oku, Yuka; Kosai, Keisuke; Ono, Yuki; Wakasu, Sho; Haratake, Naoki; Toyokawa, Gouji; Takenaka, Tomoyoshi; Tagawa, Tetsuzo; Shimokawa, Mototsugu; Nakashima, Naoki; Mori, Masaki.
Afiliação
  • Kinoshita F; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Yamashita T; Medical Information Center, Kyushu University Hospital, Fukuoka, Japan.
  • Oku Y; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Kosai K; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Ono Y; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Wakasu S; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Haratake N; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Toyokawa G; Department of Thoracic Surgery, Clinical Research Institute, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan.
  • Takenaka T; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Tagawa T; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; t_tagawa@surg2.med.kyushu-u.ac.jp.
  • Shimokawa M; Department of Biostatistics, Graduate School of Medicine, Yamaguchi University, Yamaguchi, Japan.
  • Nakashima N; Medical Information Center, Kyushu University Hospital, Fukuoka, Japan.
  • Mori M; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Anticancer Res ; 41(3): 1621-1628, 2021 Mar.
Article em En | MEDLINE | ID: mdl-33788758
ABSTRACT
BACKGROUND/

AIM:

Albumin-bilirubin (ALBI) grade is an indicator of liver dysfunction and is useful for predicting postoperative prognosis of hepatocellular carcinomas. However, the significance of ALBI grade in non-small cell lung carcinoma (NSCLC) has not been elucidated. PATIENTS AND

METHODS:

We analyzed 947 patients with pStage IA-IIIA NSCLC. We divided patients into ALBI grade 1 and grade 2/3 groups. We then analyzed the association of ABLI grade with clinicopathological characteristics and prognosis in NSCLC by using propensity-score matching.

RESULTS:

ALBI grade 2/3 was significantly associated with older age, male sex, advanced pT status, and histological type. Even after propensity-score matching, ALBI grade 2/3 patients had significantly worse cancer-specific survival (CSS) than ALBI grade 1 patients (5-year CSS 87.3% versus 92.8%; p=0.0247). In multivariate analysis, ALBI grade 2/3 was an independent predictor of CSS (HR=1.9; 95%CI=1.11-3.11; p=0.0177).

CONCLUSION:

ALBI grade was an independent prognostic factor in surgically resected NSCLC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bilirrubina / Albumina Sérica / Carcinoma Pulmonar de Células não Pequenas / Pontuação de Propensão / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bilirrubina / Albumina Sérica / Carcinoma Pulmonar de Células não Pequenas / Pontuação de Propensão / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article