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Perimenopausal women show modulation of excitatory and inhibitory neuromuscular mechanisms.
Pesonen, Heidi; Laakkonen, Eija K; Hautasaari, Pekka; Aukee, Pauliina; Kovanen, Vuokko; Sipilä, Sarianna; Finni, Taija; Tarkka, Ina M.
Afiliação
  • Pesonen H; Faculty of Sport and Health Sciences, University of Jyväskylä, P.O. Box 35, 40014, Jyväskylä, Finland. heidi.m.pesonen@jyu.fi.
  • Laakkonen EK; Faculty of Sport and Health Sciences, University of Jyväskylä, P.O. Box 35, 40014, Jyväskylä, Finland.
  • Hautasaari P; Gerontology Research Center, University of Jyväskylä, Jyväskylä, Finland.
  • Aukee P; Faculty of Sport and Health Sciences, University of Jyväskylä, P.O. Box 35, 40014, Jyväskylä, Finland.
  • Kovanen V; Department of Obstetrics and Gynecology, Pelvic Floor Research and Therapy Unit, Central Finland Central Hospital, Jyväskylä, Finland.
  • Sipilä S; Faculty of Sport and Health Sciences, University of Jyväskylä, P.O. Box 35, 40014, Jyväskylä, Finland.
  • Finni T; Gerontology Research Center, University of Jyväskylä, Jyväskylä, Finland.
  • Tarkka IM; Faculty of Sport and Health Sciences, University of Jyväskylä, P.O. Box 35, 40014, Jyväskylä, Finland.
BMC Womens Health ; 21(1): 133, 2021 03 31.
Article em En | MEDLINE | ID: mdl-33789654
BACKGROUND: Menopausal transition exposes women to an early decline in muscle force and motor function. Changes in muscle quality and function, especially in lower limbs, are crucial, as they expose individuals to increased risk of falls. To elucidate some of the related neuromuscular mechanisms, we investigated cortical inhibition and peripheral muscle twitch force potentiation in women during the early and late stages of perimenopause. METHODS: Participants were 63 women aged 48-55 years categorized as early (EP, n = 25) or late (LP, n = 38) perimenopausal according to serum follicle-stimulating hormone (FSH) levels and menstrual diaries. EP women had an irregular menstrual cycle and FSH < 25 IU/L, while LP women had an irregular cycle and > 25 IU/L. We examined motor evoked potential (MEP) and silent period (SP) elicited by transcranial magnetic stimulation (TMS), in the tibialis anterior muscle at 20%, 40%, and 60% of maximal voluntary contraction (MVC) levels, and twitch force potentiation in plantar flexors. RESULTS: EP group showed a longer SP duration in 40% MVC condition and larger motor evoked potential amplitude in 20% MVC condition compared to the LP group. No group difference was detected in twitch force potentiation; however, it correlated negatively with FSH levels. Other factors, such as age, height, body mass index, or physical activity did not explain group differences. CONCLUSIONS: Our preliminary results indicate subtle modulation in both TMS-induced inhibitory and excitatory mechanisms and twitch force potentiation in women already in the late perimenopausal stage. This suggests that the reduction of estrogens may have an accelerating role in the aging process of neuromuscular control.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Potencial Evocado Motor / Perimenopausa Limite: Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Potencial Evocado Motor / Perimenopausa Limite: Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article