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New Inhibitory Effect of Latilactobacillus sakei UONUMA on the Cholesterol Biosynthesis Pathway in Human HepG2 Cells.
Ohta-Shimizu, Miho; Fuwa, Fumiko; Tomitsuka, Eriko; Nishiwaki, Toshikazu; Aihara, Kotaro; Sato, Shinji; Nakagawa, Saori.
Afiliação
  • Ohta-Shimizu M; Department of Bio-Analytical Chemistry, Niigata University of Pharmacy and Applied Life Sciences.
  • Fuwa F; Department of Bio-Analytical Chemistry, Niigata University of Pharmacy and Applied Life Sciences.
  • Tomitsuka E; Department of Health Chemistry, Niigata University of Pharmacy and Applied Sciences.
  • Nishiwaki T; Niigata Agricultural Research Institute Food Research Center.
  • Aihara K; Niigata Agricultural Research Institute Food Research Center.
  • Sato S; Functional and Analytical Food Sciences, Niigata University of Pharmacy and Applied Life Sciences.
  • Nakagawa S; Department of Bio-Analytical Chemistry, Niigata University of Pharmacy and Applied Life Sciences.
Biol Pharm Bull ; 44(4): 485-493, 2021.
Article em En | MEDLINE | ID: mdl-33790100
Many pharmaceuticals and dietary foods have been reported to inhibit cholesterol biosynthesis, mainly by inhibiting the presqualene enzyme 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase rather than a postsqualene enzyme. In this study, we examined the inhibitory effects of Latilactobacillus sakei UONUMA on cholesterol biosynthesis, especially postsqualene, in human HepG2 hepatoma cells. We quantified cholesterol and its precursors, and the mRNA and protein levels of enzymes involved in cholesterol biosynthesis. Three L. sakei UONUMA strains exhibited new inhibitory effects on cholesterol biosynthesis and inhibited the mRNA level of sterol-delta24-reductase (DHCR24), which is involved in the postsqualene cholesterol biosynthesis pathway. These strains will be useful for the prevention and treatment of hyperlipidemia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxirredutases / Lactobacillaceae / Colesterol Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxirredutases / Lactobacillaceae / Colesterol Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article