Subacute safety assessment of recombinant Lactococcus lactis on the gut microbiota of male Sprague-Dawley rats.

Chen, Guowei; Yang, Zixin; Cao, Chunting; Xiao, Xue; Huang, Yadong; Tian, Lingmin; Bai, Weibin

Chen, Guowei; Yang, Zixin; Cao, Chunting; Xiao, Xue; Huang, Yadong; Tian, Lingmin; Bai, Weibin.

Afiliação

Chen G; Department of Food Science and Engineering, Institute of Food Safety and Nutrition, Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection, Jinan University, Guangzhou, China.
Yang Z; Department of Food Science and Engineering, Institute of Food Safety and Nutrition, Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection, Jinan University, Guangzhou, China.
Cao C; Department of Food Science and Engineering, Institute of Food Safety and Nutrition, Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection, Jinan University, Guangzhou, China.
Xiao X; Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China.
Huang Y; Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China.
Tian L; Department of Food Science and Engineering, Institute of Food Safety and Nutrition, Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection, Jinan University, Guangzhou, China.
Bai W; Department of Food Science and Engineering, Institute of Food Safety and Nutrition, Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection, Jinan University, Guangzhou, China.

J Sci Food Agric ; 101(14): 5807-5812, 2021 Nov.

Article em En | MEDLINE | ID: mdl-33792042

Assuntos

Microbioma Gastrointestinal/efeitos dos fármacos; Lactococcus lactis/genética; Probióticos/administração & dosagem; Animais; Bactérias/classificação; Bactérias/genética; Bactérias/isolamento & purificação; Avaliação Pré-Clínica de Medicamentos; Fezes/microbiologia; Rim/metabolismo; Rim/patologia; Lactococcus lactis/metabolismo; Fígado/metabolismo; Fígado/patologia; Masculino; Metalotioneína/genética; Metalotioneína/metabolismo; Probióticos/efeitos adversos; Probióticos/metabolismo; Ratos; Ratos Sprague-Dawley; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo

Palavras-chave

genetically modified microorganism; gut microbiota; lactic acid bacteria; safety assessment

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lactococcus lactis / Probióticos / Microbioma Gastrointestinal Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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