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(±)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3ß Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease.
Ismaili, Lhassane; Monnin, Julie; Etievant, Adeline; Arribas, Raquel L; Viejo, Lucía; Refouvelet, Bernard; Soukup, Ondrej; Janockova, Jana; Hepnarova, Vendula; Korabecny, Jan; Kucera, Tomas; Jun, Daniel; Andrys, Rudolf; Musilek, Kamil; Baguet, Aurelie; García-Frutos, Eva M; De Simone, Angela; Andrisano, Vincenza; Bartolini, Manuela; de Los Ríos, Cristóbal; Marco-Contelles, José; Haffen, Emmanuel.
Afiliação
  • Ismaili L; Neurosciences intégratives et cliniques EA 481, Univ. Bourgogne Franche-Comté, F-25000 Besançon, France.
  • Monnin J; Neurosciences intégratives et cliniques EA 481, Univ. Bourgogne Franche-Comté, F-25000 Besançon, France.
  • Etievant A; Neurosciences intégratives et cliniques EA 481, Univ. Bourgogne Franche-Comté, F-25000 Besançon, France.
  • Arribas RL; Servicio de Farmacología Clínica, Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, C/Diego de León, 62, 28006 Madrid, Spain.
  • Viejo L; Instituto Teofilo Hernando, Universidad Autónoma de Madrid, C/Arzobispo Morcillo, 4, 28029 Madrid, Spain.
  • Refouvelet B; Servicio de Farmacología Clínica, Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, C/Diego de León, 62, 28006 Madrid, Spain.
  • Soukup O; Instituto Teofilo Hernando, Universidad Autónoma de Madrid, C/Arzobispo Morcillo, 4, 28029 Madrid, Spain.
  • Janockova J; Neurosciences intégratives et cliniques EA 481, Univ. Bourgogne Franche-Comté, F-25000 Besançon, France.
  • Hepnarova V; Biomedical Research Center, University Hospital Hradec Kralove, Czech Republic, University of Defence, 50003 Hradec Kralove, Czech Republic.
  • Korabecny J; Biomedical Research Center, University Hospital Hradec Kralove, Czech Republic, University of Defence, 50003 Hradec Kralove, Czech Republic.
  • Kucera T; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, 66210 Brno, Czech Republic.
  • Jun D; Biomedical Research Center, University Hospital Hradec Kralove, Czech Republic, University of Defence, 50003 Hradec Kralove, Czech Republic.
  • Andrys R; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, 66210 Brno, Czech Republic.
  • Musilek K; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, 66210 Brno, Czech Republic.
  • Baguet A; Faculty of Science, Department of Chemistry, University Hradec Kralove, Rokitanskeho 62, 50003 Hradec Kralove, Czech Republic.
  • García-Frutos EM; Faculty of Science, Department of Chemistry, University Hradec Kralove, Rokitanskeho 62, 50003 Hradec Kralove, Czech Republic.
  • De Simone A; Université Bourgogne Franche Comté, INSERM, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, F-25000 Besançon, France.
  • Andrisano V; Instituto de Ciencia de Materiales de Madrid, CSIC, Cantoblanco, 28049 Madrid, Spain.
  • Bartolini M; Department for Life Quality Studies, Alma Mater Studiorum University of Bologna, Corso di Augusto, 237, 47921 Rimini, Italy.
  • de Los Ríos C; Department for Life Quality Studies, Alma Mater Studiorum University of Bologna, Corso di Augusto, 237, 47921 Rimini, Italy.
  • Marco-Contelles J; Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
  • Haffen E; Servicio de Farmacología Clínica, Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, C/Diego de León, 62, 28006 Madrid, Spain.
ACS Chem Neurosci ; 12(8): 1328-1342, 2021 04 21.
Article em En | MEDLINE | ID: mdl-33797877
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article