Coagulation and Fibrinolysis in Obstructive Sleep Apnoea.
Int J Mol Sci
; 22(6)2021 Mar 11.
Article
em En
| MEDLINE
| ID: mdl-33799528
ABSTRACT
Obstructive sleep apnoea (OSA) is a common disease which is characterised by repetitive collapse of the upper airways during sleep resulting in chronic intermittent hypoxaemia and frequent microarousals, consequently leading to sympathetic overflow, enhanced oxidative stress, systemic inflammation, and metabolic disturbances. OSA is associated with increased risk for cardiovascular morbidity and mortality, and accelerated coagulation, platelet activation, and impaired fibrinolysis serve the link between OSA and cardiovascular disease. In this article we briefly describe physiological coagulation and fibrinolysis focusing on processes which could be altered in OSA. Then, we discuss how OSA-associated disturbances, such as hypoxaemia, sympathetic system activation, and systemic inflammation, affect these processes. Finally, we critically review the literature on OSA-related changes in markers of coagulation and fibrinolysis, discuss potential reasons for discrepancies, and comment on the clinical implications and future research needs.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trombose Venosa
/
Apneia Obstrutiva do Sono
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Acidente Vascular Cerebral
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Síndrome Coronariana Aguda
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Fibrinólise
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Hipóxia
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article