Actin-Resistant DNase1L2 as a Potential Therapeutics for CF Lung Disease.

Delfino, Danila; Mori, Giulia; Rivetti, Claudio; Grigoletto, Antonella; Bizzotto, Gloria; Cavozzi, Cristian; Malatesta, Marco; Cavazzini, Davide; Pasut, Gianfranco; Percudani, Riccardo

Delfino, Danila; Mori, Giulia; Rivetti, Claudio; Grigoletto, Antonella; Bizzotto, Gloria; Cavozzi, Cristian; Malatesta, Marco; Cavazzini, Davide; Pasut, Gianfranco; Percudani, Riccardo.

Afiliação

Delfino D; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.
Mori G; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.
Rivetti C; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.
Grigoletto A; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.
Bizzotto G; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.
Cavozzi C; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.
Malatesta M; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.
Cavazzini D; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.
Pasut G; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.
Percudani R; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.

Biomolecules ; 11(3)2021 03 10.

Article em En | MEDLINE | ID: mdl-33802146

Assuntos

Actinas/metabolismo; Fibrose Cística/terapia; Desoxirribonuclease I/metabolismo; Desoxirribonuclease I/uso terapêutico; Sequência de Aminoácidos; Cálcio/metabolismo; Domínio Catalítico; Sequência Conservada; Cisteína/metabolismo; DNA/isolamento & purificação; Desoxirribonuclease I/química; Humanos; Muco; Oxirredução; Pichia/metabolismo; Plasmídeos/isolamento & purificação; Polietilenoglicóis/química; Ligação Proteica; Proteínas Recombinantes/isolamento & purificação

Palavras-chave

PEGylation; Pichia pastoris; cystic fibrosis; endonuclease; enzyme therapeutics; mucolytics

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Actinas / Fibrose Cística / Desoxirribonuclease I Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google